Adderall Interactions

Drug Interactions

Below you will find a list of Adderall drug and substance interactions, including the effects caused from one drug to the other.

adderall interactions
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Acidifying agents

(reserpine, glutamic acid HCI, ascorbic acid, guanethidine, fruit juices, etc.)

  • Lower absorption of amphetamines

Urinary acidifying agents

(sodium acid phosphate, ammonium chloride, etc.)

  • Increase urinary excretion by increasing the concentration of species of the amphetamine molecules

Adrenergic blocker

  • Hindered by amphetamines

Alkalinizing agents

  • Absorption of amphetamines may increase from gastrointestinal alkalinizing agents(sodium bicarbonate, etc.)
  • Co-administration of Adderall and alkalizing agents like antacids should be avoided.
  • Urinary excretion in amphetamines may be decreased due to urinary alkalinizing agents(acetazolamide, thiazides).

Antidepressants

  • Effects of antidepressants may be increased from amphetamines.

MAO inhibitors

  • Amphetamine metabolism is greatly hindered by MAOI antidepressants. This can increase one’s chances of headaches, hypertensive crisis, and neurological toxic effects that can even result in fatality

Antihistamines

  • Effects of antihistamines may be suppressed by amphetamines

Antihypertensives

  • Effects of of antihypertensives my be irritated by amphetamines

Chlorpromazine

  • Effects of amphetamines are hindered by chlorpromazine due to it’s blocking of dopamine and norepinephrine. Therefore, chlorpromazine can be used to treat amphetamine poisoning

Ethosuximide

  • Intestinal absorption of ethosuximide may be slowed by amphetamines

Haloperidol

  • Central stimulant effects of amphetamines are hindered by haloperidol

Lithium Carbonate

  • Lithium Carbonate may discourage the stimulatory and anorectic effects from amphetamines

Meperidine

  • Amphetamines may increase the effects of meperidine

Methenamine Therapy

  • Due to the acidifying agents found in methenaimine therapy, urinary excretion of amphetamines may be increased.

Norepinephrine

  • Effects from norepinephrine may be increased due to amphetamines

Phenobarbital

  • Absorption of phenobarbital may be slowed from amphetamines. Co-administration of phenobarbital may cause an anticonvulsant action

Phenytoin

  • Absorption of phenytoin may be slowed from amphetamines. Co-administration of phenytoin may cause an anticonvulsant action

Propoxyphene

  • Effects Amphetamine CNS stimulation may be increased from propoxyphene. In some cases, fatal convulsions may even occur.

Veratrum alkaloids

  • Effects of veratrum alkaloids are hindered by amphetamines
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